| Athletic Leadership Council | Marketing Club |
| Campus Ministry | Math League |
| Care Core | Mental Health Awareness |
| Catiamo (Choir) | Mock Trial |
| Computer Science Honor Society | Operation Smile |
| Creative Club | Peer Leaders |
| Diversity Club | Performing Arts Club |
| EPOCH Education Programs of Children Handicapped | Pre-Health and Medical Studies Society |
| Future Business Leaders of America | Red Cross Youth Club |
| First LEGO League (FLL) Team 66338 Little Sisters 1st | Spanish Club |
| First Robotics Competition (FRC) Team 8513 Sisters 1st | Strength and Conditioning |
| Forensics Club | Student Ambassadors |
| French Club | Student Council |
| Fuel for Fitness | SWENext (Society of Women Engineers) Club |
| History Club | Towerette (School Newspaper) |
| HOSA (Health Occupations Students of America) | Villa Voice (Social Media Club) |
| Investments Club | Villa Serves |
| Italian Club | Women in the World (Bible Studies) |
| Literary Magazine | Yearbook Committee |
